Sirtuin 2 Regulates Microvascular Inflammation during Sepsis
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چکیده
منابع مشابه
Sirtuin 2 Regulates Microvascular Inflammation during Sepsis
Objective. Sepsis and septic shock, the leading causes of death in noncoronary intensive care units, kill more than 200,000/year in the US alone. Circulating cell-endothelial cell interactions are the rate determining factor in sepsis inflammation. Sirtuin, a seven-member family of proteins (SIRT1-7), epigenetically controls inflammation. We have studied the roles of SIRTs 1, 3, and 6 in sepsis...
متن کاملCorrection: Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice
[This corrects the article DOI: 10.1371/journal.pone.0160431.].
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OBJECTIVE Obesity increases morbidity and resource utilization in sepsis patients. Sepsis transitions from early/hyper-inflammatory to late/hypo-inflammatory phase. Majority of sepsis-mortality occurs during the late sepsis; no therapies exist to treat late sepsis. In lean mice, we have shown that sirtuins (SIRTs) modulate this transition. Here, we investigated the role of sirtuins, especially ...
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Sepsis causes microvascular dysfunction. Increased heterogeneity of capillary blood flow results in local tissue hypoxia, which can cause local tissue inflammation, impaired oxygen extraction, and, ultimately, organ dysfunction. Microvascular dysfunction is clinically relevant because it is a marker for mortality: it improves rapidly in survivors of sepsis but fails to improve in nonsurvivors. ...
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ژورنال
عنوان ژورنال: Journal of Immunology Research
سال: 2017
ISSN: 2314-8861,2314-7156
DOI: 10.1155/2017/2648946